All supplements
Tier 2: Targeted Supportcapsule
Vitamin B6
P5P (Pyridoxal-5-Phosphate) — 25 mg
$14/month (30-day supply)
What it does
P5P is the bioactive coenzyme form of Vitamin B6 — the form your body uses directly without conversion. It supports neurotransmitter synthesis (serotonin, dopamine, GABA), methylation alongside B12 and folate, and helps regulate homocysteine. The active form is particularly important for adults whose B6 conversion enzymes decline with age.
Key benefits
- Neurotransmitter synthesis
- Methylation support
- Homocysteine control
- Energy metabolism
The evidence
Required co-factor for over 100 enzyme reactions. Active P5P form preferred over pyridoxine HCl, especially in older adults. Often paired with B12 and methylfolate for full methylation support.
Important
Doses above 100 mg/day long-term have been associated with peripheral neuropathy. 25 mg is well within safe range. Some interaction with levodopa.