Urolithin A
Mitopure-equivalent — 500 mg
What it does
Urolithin A is a metabolite produced when gut bacteria digest pomegranate ellagitannins — but only about 40% of people produce it efficiently. Direct supplementation bypasses this lottery. It activates mitophagy, the cellular process that clears out damaged mitochondria so new ones can replace them. Multiple placebo-controlled human trials in adults 40+ show measurable improvements in muscle strength and endurance.
Key benefits
- Mitochondrial renewal
- Muscle strength and endurance
- Cellular energy
- Healthspan support
The evidence
Liu et al. 2022 (JAMA Network Open) and Singh et al. 2022 (ATLAS trial) both showed significant improvements in muscle endurance and strength in adults aged 40-65. The strongest RCT evidence of any supplement-accessible longevity compound.
Important
Generally well tolerated. Not recommended in pregnancy or while breastfeeding due to lack of safety data in those populations.