Spermidine
Wheat-Germ Derived — typical dose 1.5 mg
We don’t sell Spermidine. Whether you actually need it — and at what dose — depends on your bloodwork. Get your analysis to find out.
What it does
Spermidine is a polyamine that triggers autophagy, the cellular process that clears out damaged proteins and recycles them. Highest dietary sources are wheat germ, aged cheese, and natto. The Bruneck cohort study (Eisenberg 2018) found people in the highest tertile of dietary spermidine intake had a hazard ratio of 0.76 for all-cause mortality — equivalent to roughly 5.7 years of biological age.
Key benefits
- Autophagy activation
- Cellular cleanup
- Cardiovascular support
- Healthspan signal
The evidence
Eisenberg et al. 2018 (Nature Medicine) — strong observational mortality signal in 829 adults. RCTs are smaller and mixed; the SmartAge 2022 trial missed its cognitive primary endpoint but found safety and tolerability. We frame spermidine honestly as dietary, plausible.
Where to buy
If your analysis calls for Spermidine, this is the quality, single-ingredient version we’d reach for:
Double Wood Supplements — Spermidine (99% Spermidine 3HCl) Capsules (10 mg pure spermidine / serving)The only genuinely single-ingredient spermidine we could verify — most 'wheat-germ' spermidines add thiamin and zinc. This is pure 99% spermidine (trihydrochloride) rather than wheat-germ derived.
We may earn a small referral fee if you buy through this link — it never changes our pick. We hold no inventory and have no house brand.
Important
Wheat-germ derived — contains trace gluten. Avoid if coeliac or severely gluten-sensitive. Generally well tolerated.