Tier 2: Targeted Supportcapsule

Nicotinamide Riboside

NR (NIAGEN-equivalent) — 300 mg

$59/month (30-day supply)

What it does

Nicotinamide Riboside is a precursor to NAD+, a cellular co-factor essential for energy production, DNA repair, and metabolic regulation. NAD+ levels decline by roughly 50% between ages 40 and 60. NR is the form with the deepest human trial record for raising blood NAD+ safely. We chose NR over NMN because the meta-analysed evidence is stronger and the regulatory status more stable.

Key benefits

NAD+ replenishment
Cellular energy
DNA repair support
Metabolic regulation

The evidence

Multiple human RCTs (Martens 2018, Conze 2019, Elhassan 2019) confirm NR safely raises blood NAD+ levels in older adults. Longevity endpoints unproven in humans, but the mechanism is well-supported.

Important

Generally well tolerated. Limited safety data in pregnancy. Some studies report mild flushing or GI upset at higher doses.