Methylfolate
L-5-MTHF (Calcium Salt) — typical dose 500 mcg
We don’t sell Methylfolate. Whether you actually need it — and at what dose — depends on your bloodwork. Get your analysis to find out.
What it does
L-5-MTHF is the already-methylated, bioactive form of folate. Unlike synthetic folic acid, it doesn't require the MTHFR enzyme to convert — critical because up to 40% of the population carries MTHFR polymorphisms that impair this conversion. Works with B12 to control homocysteine, a key cardiovascular risk marker.
Key benefits
- Homocysteine metabolism
- DNA synthesis and repair
- Mood regulation
- Bypasses MTHFR issues
The evidence
Essential for those with MTHFR C677T or A1298C polymorphisms (up to 40% of population). Strong evidence for homocysteine reduction when paired with B12.
Where to buy
If your analysis calls for Methylfolate, this is the quality, single-ingredient version we’d reach for:
Thorne — 5-MTHF, 1 mg Capsules (1,000 mcg L-5-MTHF / cap)Single-ingredient bioactive L-5-MTHF at 1,000 mcg from a top clinical brand.
We may earn a small referral fee if you buy through this link — it never changes our pick. We hold no inventory and have no house brand.
Important
May interact with methotrexate and certain seizure medications. Consult your doctor if on these medications.