Tier 2: Targeted Supportcapsule

Methylfolate

L-5-MTHF (Calcium Salt) — 500 mcg

$16/month (30-day supply)

What it does

L-5-MTHF is the already-methylated, bioactive form of folate. Unlike synthetic folic acid, it doesn't require the MTHFR enzyme to convert — critical because up to 40% of the population carries MTHFR polymorphisms that impair this conversion. Works with B12 to control homocysteine, a key cardiovascular risk marker.

Key benefits

Homocysteine metabolism
DNA synthesis and repair
Mood regulation
Bypasses MTHFR issues

The evidence

Essential for those with MTHFR C677T or A1298C polymorphisms (up to 40% of population). Strong evidence for homocysteine reduction when paired with B12.

Important

May interact with methotrexate and certain seizure medications. Consult your doctor if on these medications.